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Cold pressor induced pain modulation by the activation of diffuse noxious inhibitoty control for validation of diagnostic tools for early detection of chronic pain

Mammadli, Fidan (2019) Cold pressor induced pain modulation by the activation of diffuse noxious inhibitoty control for validation of diagnostic tools for early detection of chronic pain.

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Abstract:Central sensitization is crucial in the development and persistence of chronic pain, which reveals itself as increased sensitivity to nociceptive stimuli. Hence, observation of nociceptive mechanisms may provide insight into this condition and permit early interventions. This study presents a set up of a pilot experiment for investigation of the effect of diffuse noxious inhibitory control (DNIC) on nociceptive detection threshold (NDT) and evoked potentials (EP). In the experiment, a cold pressor test (CPT) was used as a conditioning stimulus to activate DNIC. Using Multiple Threshold Tracking (MTT) and Intra-epidermal Electrocutaneous Stimulation (IES), the detection threshold of participants was measured. Furthermore, corresponding cortical activity was recorded using electroencephalography. The technical feasibility of the experiment was assessed for two water temperatures, 1!C and 6!C. As a result, both experiments were found to be technically feasible. For both temperatures, the nociceptive detection thresholds considerably increased during the application of CPT and decreased after its termination independent from stimulus setting. The amplitude of the threshold was considerably higher for single pulse stimuli. Application of the CPT also reduced the amplitudes of EP components. The stimulus setting did not have a noticeable effect on the cortical response, whereas the participant response showed the highest impact on the EPs. In conclusion, both water temperatures were found to be a suitable conditioning stimulus for use in further researches.
Item Type:Essay (Bachelor)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Subject:42 biology, 44 medicine, 53 electrotechnology
Programme:Electrical Engineering BSc (56953)
Link to this item:http://purl.utwente.nl/essays/78997
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