University of Twente Student Theses


Prediction of total body electrical resistance based on limb muscle thickness : comparison of anthropometric and ultrasound measurements

Boksem, Eline (2020) Prediction of total body electrical resistance based on limb muscle thickness : comparison of anthropometric and ultrasound measurements.

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Abstract:Introduction: In many different diseases the hydration state is disrupted. Recently, a new model has been proposed to assess hydration in man. In this model measured Total body electrical resistance (TBER) is compared to the individual’s predicted normale TBER value (TBERnorm), which is inversely related to the arm muscle cross-sectional area (AMA) as assessed by conventional anthropometry. AMA is used to normalize the TBER for differences in muscle mass between subjects. However, its performance is limited in obese patients and it only corrects for the muscle mass in the arms. Aim of the study: to investigate whether prediction of TBERnorm by AMA can be improved by ultrasound (US)-based parameters of muscularity. Methods: Performance of the US and anthropometric methods was examined in 129 subjects (60 men and 69 women) ranging in age from 18 to 75 yrs and in BMI from 17.4 to 52.4 kg/m2. Measurements were performed with a portable BIA device and US measurements were performed by B-mode ultrasonography. Muscularity of the arm and leg was calculated based on upper arm and leg circumferences and fat layer thicknesses of the limbs measured by ultrasound, to yield the mean muscle layer thicknesses of arm and leg (MMTarm+leg). The linear correlation between TBER corrected for body height (TBER/L) and AMA was compared to the correlation between the resistance and the MMTarm+leg. Results: US-based MMTarm+leg, correlated better with TBER/L for men (R2=0.75, SEE= 20.2 Ω/m versus R2=0.66, SEE=23.7 Ω/m) and women (R2=0.78, SEE=23.1 Ω/m versus R2=0.62, SEE=30.5 Ω/m) than with AMA. Multiple regression between TBER/L and MMTarm+leg combined with gender as input variables showed that gender adds no significant information(P=0.10). The correlation between MMTarm+leg and TBER/L improved even further for men and women together (R2=0.85, SEE= 22.2 Ω/m). Conclusion: In conclusion, US-based MMT arm+leg measurement shows potential to optimize the prediction of TBERnorm. It remains to be established whether the improved precision achieved by US measurements is clinically meaningful and outweighs the extra workload that is introduced.
Item Type:Essay (Master)
Rijnstate hospital, Arnhem, The Netherlands
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
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