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Computation of the Control Group Size in Randomized Controlled Trials

Zande, Irene van de (2019) Computation of the Control Group Size in Randomized Controlled Trials.

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Abstract:In this paper the size needed for the control group in a randomized controlled trial is investigated. This is done by studying the fundamental Bayesian statistics that are significant for correctly claiming causal inference and by looking into how and when historical information can be used, it is possible that the historical data needs to be adjusted for covariates before it can be of use. Historic borrowing methods are compared by their mean square error (MSE), type I error, and power. A computation of the optimal number of patients needed for the current control group and a ratio including the effective sample size are included. When historical data is available on sufficiently similar previous studies, the current control group size can be reduced accordingly.
Item Type:Essay (Bachelor)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Subject:31 mathematics
Programme:Applied Mathematics BSc (56965)
Link to this item:http://purl.utwente.nl/essays/79178
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