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Evaluation of three dimensional visualisation techniques for the preoperative planning of Wilms tumour surgery

Fitski, M. (2019) Evaluation of three dimensional visualisation techniques for the preoperative planning of Wilms tumour surgery.

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Abstract:Wilms Tumour (WT) is the second most common abdominal solid tumour in children. A nephron sparing surgical procedure (NSS) is expected to reduce later risks of the treatment. However, due to unclear guidelines, surgeons remain hesitant to perform NSS. A positive surgical margin necessitates radiotherapy and chemotherapy. We evaluated imaging techniques in order to gain more insight in the patient-specific anatomy during the preoperative planning of WT patients. A non-contrast MRA (b-SSFP) scan was optimized for paediatric patients and scanned on 7 WT patients. These MRA’s were used to compute accurate 3D anatomical models of the arteries, veins, urine collection system (UCS), tumour and kidney through a developed semi-automatic segmentation algorithm. The b-SSFP sequence showed a large increase in image quality for the visualisation of the intraparenchymal arteries. We found no significant difference in CNR during the quantitative assessment. The 3D arterial models proved robust and showed a high model quality. The 3D vein and UCS models were of low model quality and unfit for clinical use. The 3D tumour and kidney models showed a high overlap and high model quality. The arterial, tumour and kidney models were fit for clinical use. We successfully evaluated a NC-MRA sequence and segmentation algorithm to improve the preoperative visualisation of Wilms Tumour patient specific anatomy.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/79655
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