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Improving the treatment of HOCM: The investigation of a patient specific cutting mould and a 3D printed heart

Bakker, J.R.P. and Goris, L.C. and Kortman, M.C.P. and Vos, R.G.J. (2019) Improving the treatment of HOCM: The investigation of a patient specific cutting mould and a 3D printed heart.

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Abstract:Hypertrophic obstructive cardiomyopathy (HOCM) is a cardiac condition which results in left ventricle outflow tract obstruction (LVOTO). The hypertrophic tissue of severe symptomatic patients can be resected using a septal myectomy. The goal of this bachelor’s thesis is to improve the treatment of HOCM. The challenges in the treatment of HOCM are described, whereupon a literature report is carried out. A plan for further investigation is given, which includes making a 3D printed- and ballistic model of the left ventricle and a patient specific 3D cutting mould, made using CMR images of the patient. The cutting mould is tested on pig hearts and ballistic heart models. The 3D prints and ballistic models visualize the size of the hypertrophic tissue. The 3D cutting mould prototype is finalised and succeeds in resecting the ballistic model’s hypertrophy. It was not clear if the visibility of the cutting mould on ultrasound was better in a fluid filled heart. The cutting mould is a promising solution to mitigate the challenges of the septal myectomy. Further research is required, but, when implementing the 3D printed heart and the cutting mould into the septal myectomy protocol, it is likely to significantly enhance the number of positive outcomes.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:44 medicine, 50 technical science in general
Programme:Technical Medicine BSc (50033)
Link to this item:https://purl.utwente.nl/essays/79724
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