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Development of a planning tool for cavity photodynamic therapy

Wassenaar, N.P.M. (2019) Development of a planning tool for cavity photodynamic therapy.

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Abstract:Superficial sino-nasal carcinomas can be treated with cavity photodynamic therapy. This therapy is based on the use of a photosensitiser, oxygen and light of a specific wavelength to ensure tumour destruction. During photodynamic therapy, a red light source is placed inside the sino-nasal cavity of the patient to illuminate the tumour. However, not only the tumour cells are sensitive for red light, also the healthy cells will be damaged. Therefore, a planning is made prior to the therapy to decide the location and output power of the light source resulting in tumour destruction and reducing the dose received by healthy tissue. The current planning method is mainly based on 2 dimensional CT slices and uses simple radiometric calculations to determine the incident light term and does not take scattering into account. In this thesis, a planning tool is developed which determines the location and output power of the light source that leads to the best illumination of the tumour using complex light distribution models and a 3 dimensional representation of the cavity.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/80275
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