University of Twente Student Theses


Ultrasound volume sensor for intravascular volume status: Clinical and technological feasibility

Wijbenga, Nynke (2020) Ultrasound volume sensor for intravascular volume status: Clinical and technological feasibility.

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Abstract:Accurate assessment of intravascular volume status remains one of the most challenging task for clinicians. Promising techniques for monitoring intravascular volume status consist of ultrasound assessment of the indexed inferior vena cava, inferior vena cava collapsibility index, and vena jugularis interna (IJV). Ultrasound assessment of the IJV is a promising, non-invasive technique for monitoring the volume status and can be repeated as often as necessary. This technique could be used to monitor a patient’s volume status in the intensive care unit, during haemodialysis or major surgery. However, the results of ultrasound assessment are highly user dependent. An ultrasound sensor, such as the SENS-U Bladder Sensor (SENS-U), could offer support in the non-invasive assessment of intravascular volume status. The aim of this study was to explore the clinical and technological feasibility of the ultrasound volume sensor to determine the intravascular volume status by measuring the IJV. Three proof of principle studies were performed. First a phantom study was conducted to explore the axial resolution of the SENS-U. Second, IJV diameter measurements were conducted on 8 healthy volunteers to further investigate the technological and clinical feasibility. Lastly, a proof of concept study was conducted during surgery to reinforce the choice of using the IJV diameter. The phantom study and the IJV measurements on healthy volunteers showed that the axial resolution needs to be improved for this application by increasing the ultrasound frequency of the SENS-U. Furthermore, the SENS-U needs to be adhered to prevent shifting during the measurements and the size of the device needs to be decreased for correct placement in the neck area. The proof of concept study provided more insights for further research and design requirements for a SENS-U to measure IJV diameters. Based on the studies, recommendations were made for the development of an ultrasound volume sensor for the assessment of intravascular volume status, including recommendations for the design of a new device, improvement of axial and temporal resolution, and the required amount of piezoelectric crystals for the transducer. Further research could obtain more insight in the change of IJV diameter during fluid shifts.
Item Type:Essay (Master)
Novioscan, Nijmegen, NL
Faculty:TNW: Science and Technology
Subject:44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
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