University of Twente Student Theses


Multichannel electrocutaneous stimulus application for nociceptive system characterization

Bundo, Silvi (2020) Multichannel electrocutaneous stimulus application for nociceptive system characterization.

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Abstract:Early detection of chronic pain would mean better treatment outcome and less clinical efforts per patient, but unfortunately appropriate diagnostic methods are lacking. A major limitation of the present NDT-EP method is the application of stimulus patterns through a single channel constant current stimulator (the AmbuStim), which can activate only one target population of fibers at a single fixed spatial location. Yet, since pathological nociceptive processing can involve altered spatial or multimodal integration, applying a series of electrocutaneous stimuli to more than one location on the skin, or using more than one type of electrode for targeting different fiber populations, may provide better insight for nociceptive system characterization and may allow early interventions. In order to permit such experiments, this study presents the full approach of extending the current experiment setup, with the possibility of multichannel stimulation by implementing the OctoStim, an 8-channel constant current stimulator, wirelessly operated from LabVIEW. The generation of calibrated stimuli is demonstrated for this extended setup via a standard calibration program in MATLAB. As a result, the OctoStim stimulator’s embedded software was successfully updated, it generates calibrated stimuli in all 8 channels and proves to be feasible for multichannel NDT tracking experiments in human subjects.
Item Type:Essay (Bachelor)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Subject:42 biology, 44 medicine, 53 electrotechnology
Programme:Electrical Engineering BSc (56953)
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