University of Twente Student Theses
Measuring vasomotor response in abdominal aortic aneurysm patients : a cool innovation toward cardiovascular event prediction
Jansen, A.S. (2020) Measuring vasomotor response in abdominal aortic aneurysm patients : a cool innovation toward cardiovascular event prediction.
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| Abstract: | Objective: To develop an objective method to examine the vasomotor response and investigate this vasomotor response in the common carotid artery (CCA) and the abdominal aorta in both healthy participants and abdominal aortic aneurysm (AAA) patients. Future studies will use this information to develop a method to predict cardiovascular events in AAA patients. Method: The vasomotor reactivity test (VRT) was performed on 20 healthy young subjects and 11 AAA patients. The VRT consisted of a ultrasound measurement during baseline (30 sec) and the exposure of one hand into ice water (3 min). The ultrasound measurements of both arteries were performed simultaneously. The vasomotor response was defined by mean baseline diameter, area under the curve (AUC), max diameter change, max peak, time to peak, slope, duration of response, AUC of response, effective diameter change and impact factor. The parameters were compared for both arteries and both groups. Results: The maximum diameter change for the abdominal aorta is 4.9% [2.5,8.2] in the healthy young group, and -2.3% [-3.7,0.7] in the AAA group. The maximum diameter change for the CCA is 3.5% [-1.8,5.7] in the healthy group versus 1.4% [-3.0,2.2] in the AAA group. More parameters were significantly different for the abdominal aorta than the CCA when comparing both groups. The healthy group showed more vasodilation in response to the VRT than the AAA group for both arteries. Conclusion: The parameters can objectively examine the vasomotor response. The vasomotor response of the abdominal aorta and CCA is altered in the presence of an AAA, which is promising for the development of a method to predict cardiovascular events. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine, 50 technical science in general |
| Programme: | Technical Medicine MSc (60033) |
| Link to this item: | https://purl.utwente.nl/essays/80984 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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