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Searching for the cause of the SuperParamagnetic Quantifier measurement drift

Schlief, J.G.L. (2020) Searching for the cause of the SuperParamagnetic Quantifier measurement drift.

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Abstract:Research into superparamagnetic particles has surged over the last decades. With it comes the need to characterize and quantify these particles for various applications. One device capable of doing so is the SuperParamagnetic Quantifier (SPaQ). With differential magnetometry (DiffMag) it quantifies superparamagnetic iron oxide nanoparticles (SPIONs), and with a related technique it measures the derivative of the magnetization curve dM/dH. These latter measurements present poor reproducibility in the form of drift. This drift prevents comparison of the SPaQ measurements with similar devices and encumbers characterization. Repeated measurements of Sienna+ and tattle tape have shown that the sample does not play a role in the occurring drift. Temperature measurements have shown that an increasing system temperature does affect the picked-up signal. However, with a reference measurement, this is corrected for. The observed drift can be accounted for by an imbalance of the gradiometric set-up, but the origin of the imbalance remains unknown. Augmentations to the SPaQ can be made to ensure it is appropriate for its intended applications. The used excitation sequence can be altered to more closely represent the DiffMag approach used in other applications, such that the SPaQ can be used for DiffMag protocol optimization. Sample temperature control might be desired too, for particle characterization. The observed drift remains to be overcome, but other hardware augmentations are less essential.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Programme:Biomedical Engineering MSc (66226)
Link to this item:http://purl.utwente.nl/essays/81307
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