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Mechanical power in children mechanically ventilated with high-frequency oscillation ventilation

Swinkels, Daphne and Weijland, Robin and Hoekstra, Sigri and Dort, Wouter van (2020) Mechanical power in children mechanically ventilated with high-frequency oscillation ventilation.

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Abstract:Introduction: Ventilator-Induced Lung Injury (VILI) is an injury that is caused by mechanical ventilation. The mechanisms causing VILI can be summarised in one variable, the mechanical power (MP). High Frequency Oscillation Ventilation (HFOV) is a technique that could limit the risk of VILI. In contrast to different types of conventional mechanical ventilation (CMV), there are no equations for MP in HFOV available yet. This study’s purpose is to determine the MP in HFOV in a mechanical lung model and to evaluate the correlation with different variables (power setting, CDP, frequency, lung compliance and lung resistance) for six different tube sizes. Methods: Data of flow, oscillator pressures and lung pressures for different variables were used from a previously conducted Bench Study. The elastic MP (MPED) was calculated in different ways, by multiplying flow and pressure difference (Posc-Plung) and by taking the integral of the PV-loop. The resistive MP (MPRD) was calculated by multiplying the resistance with flow^2. The results were analysed using multivariable regression analysis. Results: Our results include multivariable prediction models and correlations between the different variables and MP for each tube. One tube was left out due to faults in the measurement data. All other results had a significance of p<0.001. When using large tubes, the calculated MP was relatively high in comparison with smaller tubes. Conclusion: We were able to determine the influence of different parameters on the MP in HFOV. Future trials are needed to determine whether or not the calculated MP in HFOV is a sufficient predictor of VILI.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine BSc (50033)
Link to this item:http://purl.utwente.nl/essays/81513
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