University of Twente Student Theses


The resistive-pulse technique as a method for determining spermatozoa morphology

Nijenhuis, W.J.G. (2020) The resistive-pulse technique as a method for determining spermatozoa morphology.

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Embargo date:3 July 2025
Abstract:To improve spermatozoa analysis for the livestock industry a novel method using microfluidic systems is developed. The resistive-pulse technique is a microfluidic system that has been used for detecting and sizing particles passing through a micropore but not yet for determining the exact shape of a particle. To determine the morphology of spermatozoa using the resistive-pulse technique, this study evaluates three methods for making a suitable micropore design that differentiates the resistive pulses of different shaped spermatozoa. The first two methods are based on mathematical models that approximate the behaviour of the resistive-pulse system and they show that information about a particle morphology can be found in the slope of its current pulse. The third method uses current pulses from simulations to show that short constrictions in a micropore can differentiate particles with the same volume but a different shape better than constrictions of greater length. The results from this study could help in developing a technique that can compete with computer aided sperm analysis currently in use.
Item Type:Essay (Bachelor)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Subject:46 veterinary medicine, 50 technical science in general, 53 electrotechnology
Programme:Electrical Engineering BSc (56953)
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