University of Twente Student Theses


Quantification of calcification with dual energy imaging in peripheral arterial disease

Simons, BSc Michelle V. (2020) Quantification of calcification with dual energy imaging in peripheral arterial disease.

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Embargo date:25 September 2025
Abstract:Aim of this thesis is to explore the possibilities of quantifying arterial calcification in peripheral arterial disease. This results in a combination of a phantom study and the first-in-human results of a clinical trial describing the need of arterial calcification quantification. The general introduction describes the clinical and technical background followed by the subsequent research objectives. Chapter 1 represents the results of a phantom study performed to test the possibilities of spectral scanning and the potential of quantifying calcification. Chapter 2 describes the research protocol for the first-in-human use of a DMUA/HIFU therapy as a new non-invasive intervention. Chapter 3 is a case report about the first-in-human experience with DMUA/HIFU therapy as treatment of atherosclerotic lesions in the femoral artery. The general conclusion and future perspectives section describes the potential of the DMUA/HIFU system, currently an investigational medical device, as new way of treating atherosclerotic lesions in combination with the outlook on peripheral arterial calcification quantification.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
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