University of Twente Student Theses
High-frequency stimulation and time-frequency analysis for the validation of the MTT-EP protocol
Marsili, F. (2020) High-frequency stimulation and time-frequency analysis for the validation of the MTT-EP protocol.
PDF
16MB |
Abstract: | At the University of Twente, research investigating the underlying mechanisms of pain is conducted using the ’Multiple Threshold Tracking and Evoked Potentials’ (MTT-EP) protocol. In the MTT-EP protocol, nociceptive stimuli are delivered around the individuals’ detection threshold using intra-epidermal electrical stimulation (IES) and neural processing of pain stimuli is simultaneously recorded using EEG. Previous results demonstrated that stimulus parameters play a significant role in modulating evoked potentials responding to noxious stimuli. While the MTT-EP protocol has been thoroughly investigated and already showed significant results as objective and quantitative measurement of nociception, further studies need to be conducted in order to validate the MTT-EP protocol as diagnostic tool for the assessment of chronic pain conditions. In this graduation assignment, an experimental protocol is designed introducing the use of HFS-induced secondary hyperalgesia with the MTT-EP protocol. Furthermore, time-frequency analysis of EEG data recorded during the MTT-EP protocol unveiled the frequency contents of neuronal activations elicited by nociceptive stimuli; while the LMM identified the effect of stimulus parameters in modulating neuronal oscillations. As result, it has been concluded that time-frequency analysis is a useful tool to understand the functional role of neuronal responses and can be used to further understand nociceptive processing. |
Item Type: | Essay (Master) |
Faculty: | TNW: Science and Technology |
Subject: | 44 medicine |
Programme: | Biomedical Engineering MSc (66226) |
Link to this item: | https://purl.utwente.nl/essays/84374 |
Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
Repository Staff Only: item control page