University of Twente Student Theses


High-frequency stimulation and time-frequency analysis for the validation of the MTT-EP protocol

Marsili, F. (2020) High-frequency stimulation and time-frequency analysis for the validation of the MTT-EP protocol.

[img] PDF
Abstract:At the University of Twente, research investigating the underlying mechanisms of pain is conducted using the ’Multiple Threshold Tracking and Evoked Potentials’ (MTT-EP) protocol. In the MTT-EP protocol, nociceptive stimuli are delivered around the individuals’ detection threshold using intra-epidermal electrical stimulation (IES) and neural processing of pain stimuli is simultaneously recorded using EEG. Previous results demonstrated that stimulus parameters play a significant role in modulating evoked potentials responding to noxious stimuli. While the MTT-EP protocol has been thoroughly investigated and already showed significant results as objective and quantitative measurement of nociception, further studies need to be conducted in order to validate the MTT-EP protocol as diagnostic tool for the assessment of chronic pain conditions. In this graduation assignment, an experimental protocol is designed introducing the use of HFS-induced secondary hyperalgesia with the MTT-EP protocol. Furthermore, time-frequency analysis of EEG data recorded during the MTT-EP protocol unveiled the frequency contents of neuronal activations elicited by nociceptive stimuli; while the LMM identified the effect of stimulus parameters in modulating neuronal oscillations. As result, it has been concluded that time-frequency analysis is a useful tool to understand the functional role of neuronal responses and can be used to further understand nociceptive processing.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Biomedical Engineering MSc (66226)
Link to this item:
Export this item as:BibTeX
HTML Citation
Reference Manager


Repository Staff Only: item control page