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Accelerometric quantification of MDS-UPDRS motor measurements in Parkinson’s Disease

Smid, Annemarie (2020) Accelerometric quantification of MDS-UPDRS motor measurements in Parkinson’s Disease.

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Embargo date:December 2050
Abstract:Motor symptoms like tremor and bradykinesia are characteristic for Parkinson’s Disease (PD). The internationally standardized MDS Unified Parkinson’s Disease Rating Scale (MDSUPDRS) is the current gold standard for evaluating these symptoms. Although this scale is partly based on quantitative measures, recent research showed that the MDS-UPDRS is subjective and has a high inter- and intra-rater variability. So, the research on and clinical care of PD patients currently depends on subjective evaluations of tremor and bradykinesia. Therefore, there is need for a reliable and rater-independent measurement method for monitoring motor symptoms in PD. Advances in movement sensor technology like 3D accelerometry allow evaluation of motor symptoms using purely objective measures. Yet, it is still unclear how accelerometric measures relate to MDS-UPDRS ratings. Therefore, the feasibility of accelerometric measurements to quantify the MDS-UPDRS was investigated in this study. 7 PD patients undergoing neurosurgical treatment and 13 healthy control subjects were included. Both groups underwent tremor and bradykinesia tests according to MDS-UPDRS criteria. Accelerometric measurements were performed at the index fingers. Quantitative measures were calculated from the 3D acceleration data, e.g. amplitude and power for tremor tests and time per tap and amplitude decrease for finger tapping (bradykinesia) tests. The relationship between MDS-UPDRS scores and quantitative metrics calculated from the accelerometric data was investigated. The findings for the tremor measurements in both the healthy and the patient group were in line with previous research, namely a logarithmic relationship with the given MDS-UPDRS tremor scores. In both the healthy and the patient group, a relatively large variation was found in the tapping amplitude and time per tap of bradykinesia measurements. Accelerometric outcome measures from the rest tremor and postural tremor tests showed a relatively high correlation (r >0.61) with the MDS-UPDRS tremor scores. Accelerometric measures from the kinetic tremor and bradykinesia tests did not correlate well with the given MDS-UPDRS scores, mainly due to natural variation in these tests. This study showed that accelerometric measurements are a feasible option for quantifying the MDS-UPDRS rest tremor and postural tremor tests. However, discrepancies were found between objective kinetic tremor and bradykinesia tests outcome measures and the MDS-UPDRS ratings. Therefore, further research is necessary on the relationship between quantitative MDSUPDRS measures and accelerometric outcome measures, especially for kinetic tremor and bradykinesia tests.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Programme:Technical Medicine MSc (60033)
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