University of Twente Student Theses

Login

A retrospective cohort study on late, treatment-induced morbidity after primary and adjuvant treatment in breast cancer patients

Golstein, G.C.J. (2021) A retrospective cohort study on late, treatment-induced morbidity after primary and adjuvant treatment in breast cancer patients.

[img] PDF
849kB
Abstract:Background: This study compares available medical records of Ziekenhuis Groep Twente and Medisch Spectrum Twente and the Comprehensive Cancer Organization to research the incidence of these long-term and late effects after different breast cancer therapies. Method: A cohort study is performed existing of three cohorts. The data is retrospectively collected, ordered and compared for occurrence of late effects 10-15 years after different breast cancer therapies. Analysis is done by creating confounder adjusted Cox-regression hazard ratios, and Kaplan-Meier analysis. Results: Ten years post-surgery, cohort 2 and 3 show increased occurrence of fatigue and lymphedema of the arm compared to the control group. Cohort 1 had significantly more occurrences of bowel/anal diseases than cohort 2 and 3, while the latter cohorts have an added risk for the development of these adverse effects due to more extensive adjuvant therapy. Conclusion: This study did find evidence for significant differences in outcomes, some are expected while other were remarkable. To increase the quality of informed decisions by patient and healthcare alike, further research is required by increasing population sample and the addition of Patient reported outcome measures (PROMs).
Item Type:Essay (Master)
Clients:
IKNL, Nederland
ZGT, Hengelo, Nederland
MST, Enschede, Nederland
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Health Sciences MSc (66851)
Link to this item:https://purl.utwente.nl/essays/86295
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page