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Reconstructing object shape from impedance measurements in a known microfluidic channel geometry

Lin, S.L. (2021) Reconstructing object shape from impedance measurements in a known microfluidic channel geometry.

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Abstract:In this research a new method is proposed for object shape analysis using impedance measurements of a suspended non-conducting object passing through a microfluidic channel. The method composes a system of resistance equations for discrete object positions as object passes through the channel. This system is then combined with the impedance measurement at each point. The solution of the system of equations is formed by the crosssectional shape of the object. A computational optimizer is used to find the optimal solution to this system that approaches the shape of the object. Shape reconstructions from impedance data generated with COMSOL simulations showed the capability of this method to distinguish shape characteristics typically seen in (abnormal) sperm morphology. However, some artifacts were also present due to simplifications in the resistance model. Experimental measurements of spherical beads lead to shape reconstructions that were within 20% of the object size, but had too many artifacts to say they were of the same shape as the examined object. The experiments have shown the need for further improvement in the setup before practical results can be obtained
Item Type:Essay (Master)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Subject:53 electrotechnology
Programme:Electrical Engineering MSc (60353)
Link to this item:https://purl.utwente.nl/essays/86558
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