University of Twente Student Theses


Delivery of dexamethasone and ketamine by iontophoresis in chronic pain patients

Bedem, A. van den and Boutkan, N.J. and Schlepers, E. and Veen, M.G.L. van (2021) Delivery of dexamethasone and ketamine by iontophoresis in chronic pain patients.

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Abstract:In this study the goal was to get more insights into the mechanisms of iontophoresis by which dexamethasone and ketamine permeate through the skin and why iontophoresis is effective in chronic pain patients. Firstly, extensive literature research has been performed with a focus on the relevant working mechanisms, status of iontophoresis and models used to simulate the treatment. Secondly, a visit to the clinic gave insights into the practical application of iontophoresis. Furthermore, an in vitro experiment has been conducted in which the passive diffusion and iontophoresis of Dexamethasone Sodium Phosphate (DEX-P) are compared overtime. Lastly, the residual DEX-P in the donor compartment after treatment at the clinic has been measured. Literature shows positive results of iontophoresis over passive diffusion of DEX-P and esketamine in pain treatment. However, in the experiment no difference was measured and the delivery seemed low. Therefore, more research is needed to investigate the role of iontophoresis in treatment of chronic pain.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Programme:Technical Medicine BSc (50033)
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