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Designing a multi-channel continuous perfusion system for 3D blood vessel-on-chip with viscous finger patterning

Nagatomo, Y. (2021) Designing a multi-channel continuous perfusion system for 3D blood vessel-on-chip with viscous finger patterning.

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Abstract:Cardiovascular disease is one of the leading cause of deaths worldwide, but there has yet to be an efficient method for drug testing, with animal testing being both unethical and unrepresentative of human physiology. Recent advancements in research on Vessel-on-Chip (VoC) devices open up the possibility for in vitro drug testing. However, these microfluidic devices do not have a method to culture multiple cells in a 3D accurate environment under continuous perfusion. This paper discusses the challenges of VoC systems and evaluates 2 existing perfusion mechanisms - the UniChip and standardized fluidic circuit board (FCB). The results revealed challenges for the UniChip design in parallelization of the channels because high hydraulic resistances are required in the supporting channels to obtain desired shear rates. On the contrary, the standardized approach of the FCB shows more promise due to many existing examples for parallelization and continued development of microfluidic building blocks. In the long run, this approach should allow for a simplified method of research applications and automation due to the ease of integrating sensors and additional components. The paper also addresses the challenges with the viscous finger patterning technique and fabrication of the chip that should be considered.
Item Type:Essay (Bachelor)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Programme:Electrical Engineering BSc (56953)
Link to this item:http://purl.utwente.nl/essays/88454
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