University of Twente Student Theses


Optimized MRI techniques for image-guided holmium-166 SIRT

Wijk, M.W.M. van (2021) Optimized MRI techniques for image-guided holmium-166 SIRT.

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Abstract:Selective internal radiation therapy (SIRT) is a therapy for inoperable malignancies within the liver. During SIRT, an amount of microspheres are administered in the hepatic artery. These microspheres then irradiate the liver tissue using high-energetic β-radiation. A unique property of holmium-166 microspheres is that due to the γ-radiation and due to paramagnetic properties these microspheres can be imaged with both SPECT and MRI. These imaging possibilities are normally used for the evaluation of the treatment after the procedure. However, recently a study was performed on image-guided SIRT at the Radboudumc. The ultimate goal of image-guided SIRT is to be able to adjust the administered dose and injection positions during the procedure, based on MR imaging, thereby precisely irradiating the tumours while minimizing healthy liver dose. Therefore, a good workflow and accurate dosimetry is needed. Research has been done on both the workflow and techniques of the MR quantification, to find alternative or optimized methods for image-guided SIRT. With the results of this thesis several steps have been made in optimizing image-guided SIRT. With these new insights a new clinical study will be started in the near future, focusing on the feasibility of performing MRI quantification and decision-making during the procedure.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:30 exact sciences in general, 33 physics, 44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
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