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Investigations into the use of a radiofrequency needle as temperature sensor using photoacoustics

Giesen, Jitse (2021) Investigations into the use of a radiofrequency needle as temperature sensor using photoacoustics.

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Abstract:Radiofrequency ablation (RFA) is a well-established treatment option for patients with Hepatic Cellular Carcinomas (HCC). One of the major limitations on the effectiveness of RFA is a high recurrence rate, which is reported to be 42%–70% at 5-years after initial RFA treatment.1 Recurrence can be caused by incomplete ablation, which can happen due to insufficient monitoring of the ablation temperature during treatment. Photoacoustic thermometry has been investigated as a way to improve monitoring and therefore clinical outcome. In this study the viability of a new method of photoacoustic thermometry based on the signal arising from the ablation needle tines has been investigated. An experimental set-up was built to measure the photoacoustic response at different temperatures of different samples. Thereafter, the relation between the PA amplitude and temperature for the RFA needle tines was measured. Furthermore, the concept of temperature determination based on the PA signal from the RFA needle tines was demonstrated in two proof-of-principle experiments. It is concluded that the technique has great promise and the idea of using the PA signal generated by the tines to monitor temperature seems viable but further research is needed.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine, 50 technical science in general
Programme:Biomedical Engineering MSc (66226)
Link to this item:http://purl.utwente.nl/essays/88525
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