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Enabling Chip Characterization & Providing Chip Information : Characterizing fluid flow in a microphysiological system using PIV-experiments, Lattice-Boltzmann and COMSOL Multiphysics simulations and creating a tool to provide this information to users with a scenario-based rapid-prototyping co-creation process

Kaal, Joris (2021) Enabling Chip Characterization & Providing Chip Information : Characterizing fluid flow in a microphysiological system using PIV-experiments, Lattice-Boltzmann and COMSOL Multiphysics simulations and creating a tool to provide this information to users with a scenario-based rapid-prototyping co-creation process.

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Abstract:Newly developed microfluidic microphysiological systems form a great opportunity for drug development, disease modelling and toxicological analyses. They are chips with the size of a credit card with microchannels and compartments for fluidics inside of them. These channels and compartments are housing and connecting different organ models. Berlin-based company TissUse GmbH is one of the pioneers in this field. For the users of microphysiological systems, knowledge of the flow circumstances inside their system is vital. TissUse GmbH wishes to further extend their knowledge of the flow inside their own chips. This work compares three methods to determine the flow characteristics inside a microphysiological system. µPIV experiments were followed by Lattice-Boltzmann simulations on the Cartesius supercomputer. This was supplemented by simulations performed with COMSOL Multiphysics. It concludes that, for now, µPIV is still the most suitable means. On top of that, this work takes the hypothetical data from this characterization and performs a design process strongly involving all stakeholders. In the end a user interface for a digital tool is designed based on TissUse's vision, stakeholder and user wishes and an academic study of information visualization and user interface design. The result was tested with end-users and considered ready for implementation.
Item Type:Essay (Master)
Clients:
TissUse GmbH, Berlin, Germany
Faculty:ET: Engineering Technology
Subject:01 general works, 30 exact sciences in general, 31 mathematics, 33 physics, 42 biology, 44 medicine, 52 mechanical engineering
Programme:Mechanical Engineering MSc (60439)
Link to this item:http://purl.utwente.nl/essays/88558
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