University of Twente Student Theses


Electrical cardiometry for measuring cardiac output in critically ill newborns

Lokhorst, Chantal (2021) Electrical cardiometry for measuring cardiac output in critically ill newborns.

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Embargo date:1 September 2022
Abstract:Patients admitted to a neonatal intensive care unit (NICU) are (continuously) haemodynamically monitored. Assessment of the cardiac output (CO) can assist in timely recognition of hypoperfusion and early stages of shock. Measuring CO in neonates is complex, as most of the methods used in adults cannot be applied in neonates. Electrical cardiometry (EC) is a method based on bioimpedance that continuously measures CO. Research validating EC in (preterm) neonates is scarce. Therefore, the aim of this study is to validate EC against transthoracic echocardiography (TTE). Patients admitted to the NICU of the RadboudUMC Nijmegen, the Netherlands, with a gestational age between 26 and 42 weeks were included. Bland-Altman analysis was performed to determine the agreement between the two methods. 43 echocardiography’s were performed in 19 neonates with a median (IQR) gestational age of 29.4 (28.1 – 31.0) weeks and a weight of 1109 (983.5 – 1380) g. Mean ± SD of COEC, LVOTTE, was 224 ± 40, 244 ± 98, mL/min/kg, respectively. Bland-Altman analysis of COEC and LVOTTE resulted in a mean bias and precision (1.96×SD) of -19.6 and 212 ml/min/kg with a percent bias of -8% and a percent error of 81.6%. No interchangeability was found between EC and TTE.
Item Type:Essay (Master)
Radboudumc, Nijmegen, Nederland
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
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