University of Twente Student Theses
Arterial Spin Labelling Based Cerebral Blood Flow in Depressed Patients Receiving Electroconvulsive Therapy
Aalbregt, E. (2021) Arterial Spin Labelling Based Cerebral Blood Flow in Depressed Patients Receiving Electroconvulsive Therapy.
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| Abstract: | Background: For both, patients and their relatives, the burden of electroconvulsive therapy (ECT) increases with the severity of postictal symptoms. Vasoconstriction-induced hypoperfusion seems to be a candidate mechanism to induce these symptoms. We aim to assess both, the short term (postictal) and long term effects (week to months after treatment) of ECT on the CBF. Methods: To assess perfusion, patients typically underwent six arterial spin labelling magnetic resonance imaging (ASL MRI) scans. An automated imaging pipeline was created to calculate global (g)CBF and regional (r)CBF. Linear mixed-effects models were utilised for the statistical analyses. The antidepressant effect of ECT was assessed with the Hamilton Rating Scale for Depression (HRSD). Results: Postictal gCBF was not statistically different from baseline in the included patient population. Longer seizure duration resulted in a lower postictal perfusion (p=0.04). Normalised gCBF had correlated with normalised HRSD-score (p=0.02) in the same time frame. Responders had a lower mean baseline gCBF value compared to non-responders and showed an increase in gCBF over the ECT course whereas non-responders showed a decrease. Conclusions: The hypothesised postictal hypoperfusion was not observed in the current study population. Longer seizure duration was correlated with lower postictal gCBF values. The antidepressant effect of ECT seems to be related to overall perfusion, however, this effect could not be replicated regionally. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Technical Medicine MSc (60033) |
| Link to this item: | https://purl.utwente.nl/essays/89079 |
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