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APTw imaging in paediatric brain tumours: no waste of time and energy : Assessment of precision and feasibility at 3T and 7T MRI

Obdeijn, I.V. (2021) APTw imaging in paediatric brain tumours: no waste of time and energy : Assessment of precision and feasibility at 3T and 7T MRI.

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Full Text Status:Access to this publication is restricted
Embargo date:1 January 2023
Abstract:INTRODUCTION: Paediatric brain tumours are evaluated with conventional MRI during treatment. However, conventional MRI is not always conclusive in the evaluation of treatment. To improve diagnosis and treatment evaluation of paediatric brain tumours non-invasive characterisation of tumour metabolism could offer a solution. New advanced MR techniques of which amide proton transfer weighted (APTw) imaging has potency to become an imaging biomarker for treatment response. We investigate to what extent APTw imaging can aid in the evaluation of treatment in paediatric brain tumours considering the precision in a phantom and healthy subjects at both 3T and 7T MRI. In addition, feasibility of APTw imaging at 7T MRI is assessed in paediatric brain tumours. RESULTS: APTw maps generated by Lorentzian fitting show the potential to discern longitudinal difference in APTw values concerning precision, wCV ≤ 20%. Processing of z-spectra with Lorentzian fitting improved the repeatability. The repeatability is not affected by the brain region and brain tissue type. Nevertheless, the repeatability drops when considering small volume of brain tissue segments. Longitudinal change in average APTw values of paediatric brain tumours were superior to the intrasubject variability. CONCLUSION: APTw maps belonging to full z-spectrum acquisitions and processed with Lorentzian fitting, facilitate the use of APTw imaging as an imaging biomarker for brain tumour metabolism. The APTw maps of paediatric brain tumours seem to indicate the feasibility of APTw imaging at 7T for the evaluation tumour metabolism.
Item Type:Essay (Master)
Clients:
UMC Utrecht, Utrecht, Nederland
Faculty:TNW: Science and Technology
Subject:44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
Link to this item:https://purl.utwente.nl/essays/89155
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