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Modeling renal autoregulation in a hemodynamic, mathematical model of a pregnant woman

Ochten, M. van (2022) Modeling renal autoregulation in a hemodynamic, mathematical model of a pregnant woman.

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Abstract:Introduction: The maternal cardiovascular system changes during pregnancy to ensure an adequate circulation for fetal development and growth. Inability to adapt to these physiological changes can lead to vascular complications. Mathematical models can be used to gain insight in cardiovascular physiology. The aim of this study is to develop an accurate, robust and transparent model for renal autoregulation during pregnancy. Methods: Renal autoregulation is modeled and implemented in a hemodynamic model of a pregnant woman. The renal autoregulation model will aim to maintain glomerular pressure and glomerular filtration rate by inducing a change in the resistance of the afferent arteriole. Results: The effect of the renal autoregulation model on renal blood flow and radius of the afferent arteriole was compared to observations in previous research. Our complete model had a maximum deviation of 2% in change in renal blood flow and 7% in afferent radius. Discussion and conclusion: This is the first study to present a hemodynamic model of a pregnant woman with renal autoregulation implemented. The physiological outcomes are comparable to observations in the literature. Further research should be performed on other mechanisms involved in renal autoregulation, to improve the performance of the hemodynamic model of a pregnant woman.
Item Type:Essay (Master)
Clients:
Radboudumc
Faculty:TNW: Science and Technology
Programme:Technical Medicine MSc (60033)
Link to this item:https://purl.utwente.nl/essays/89394
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