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Drug-Loaded IRONSperm Clusters: Modeling, Actuation and Ultrasound Imaging

Middelhoek, BSc. Kaz I.N.A. (2022) Drug-Loaded IRONSperm Clusters: Modeling, Actuation and Ultrasound Imaging.

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Full Text Status:Access to this publication is restricted
Embargo date:1 January 2023
Abstract:Individual biohybrid microrobots have the potential to perform biomedical in vivo tasks such as remote-controlled drug and cell delivery and minimally invasive surgery. This work demonstrates the formation of biohybrid sperm templated clusters under the influence of an external magnetic field and essential functionalities for wireless actuation and drug delivery. Ferromagnetic nanoparticles are electrostatically assembled around dead sperm cells, and the resulting nanoparticle-coated cells are magnetically assembled into three-dimensional biohybrid clusters. The aim of this clustering is threefold: First, to enable rolling locomotion on a nearby solid boundary using a rotating magnetic field; second, to allow for non-invasive localization; third, to load the cells inside the cluster with drugs for targeted delivery. A magneto-hydrodynamic model captures the rotational response of the clusters in a viscous fluid, and predicts an upper bound for their step-out frequency, which is independent of their volume or aspect ratio. Below the step-out frequency, the rolling velocity of the clusters increases nonlinearly with their perimeter and actuation frequency. During rolling locomotion, the clusters are localized using ultrasound at a relatively large distance, which makes these biohybrid clusters promising for deep-tissue applications. Finally, we show that the estimated drug load scales with the number of cells in the cluster and can be retained for more than 10 hours. The aggregation of microrobots enables them to collectively roll in a predictable way in response to an external rotating magnetic field, and enhances ultrasound detectability and drug loading capacity compared to the individual microrobots. The favourable features of biohybrid microrobot clusters place emphasis on the importance of the investigation and development of collective microrobots and their potential for in vivo applications.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:50 technical science in general
Programme:Biomedical Engineering MSc (66226)
Link to this item:https://purl.utwente.nl/essays/89481
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