University of Twente Student Theses


Investigating brain activity patterns related to performing a Go/No-Go task under cued and uncued conditions

Jansen, R.M. (2022) Investigating brain activity patterns related to performing a Go/No-Go task under cued and uncued conditions.

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Abstract:Parkinson’s Disease is one of the most common neurodegenerative disorders worldwide. One of the symptoms of Parkinson’s Disease is a decreased response inhibition ability. The current treatments for Parkinson’s Disease, Levodopa and deep brain stimulation do not provide a way to improve response inhibition. Another possible treatment is known as cueing, a neuromodulation technique based on the presentation of external, rhythmical stimuli to the patient. Cueing has been shown to improve gait parameters of patients, so it might also have influence on the response inhibition ability of patients with Parkinson’s Disease. However, its working mechanisms are not exactly known. Therefore, to expand the knowledge about the working mechanisms of cueing, the aim of the current study is to investigate the influence of certain types of cues on response inhibition. Twenty healthy subjects performed a Go/No-Go task, a method of simulating response inhibition under the influence of three types of cues. Under the first of these conditions, the participants received No Cues, under the second they received Slow Cues with a frequency of 0.75 Hz, and under the last condition they received Fast Cues with a frequency of 3 Hz. During the performance of the task, the electroencephalograms (EEG) of the participants were collected, as well as their reaction times and the amount of mistakes they made. The EEG data was processed to find event related (de)synchronisations (ERD/ERS) and event related potentials (ERP) in response to either a Go or a No-Go stimulus. As a control condition for the reaction times, a Go-Only task was added to the experiment. The reaction times and amount of mistakes that were made did not show significant differences between cueing conditions. The ERP has shown that the Go/No-Go task worked as predicted, but did not show any significant differences between cueing conditions when looking at N2 and P3 peak amplitude and latency. No significant differences between cueing conditions were found in the ERD/ERS. On the healthy subjects, cueing did not have any effects. However, it was proposed that the role of the cerebellum was not to take over the response inhibition function of the basal ganglia, but provides a more supporting role. In patients with Parkinson’s Disease, this supporting role might become more leading as the basal ganglia are defective. Cueing might provide a solution then for their problems with response inhibition as well.
Item Type:Essay (Master)
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Programme:Biomedical Engineering MSc (66226)
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