University of Twente Student Theses


EEG alpha power in acute and subacute patients with mild traumatic brain injury

Meijer, M. (2022) EEG alpha power in acute and subacute patients with mild traumatic brain injury.

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Abstract:Background: Mild traumatic brain injury (mTBI) is a major cause of death worldwide and in the Netherlands. Attention is compromised in mTBI, which can be measured through reaction time, eye-tracking and electroencephalography (EEG) measurements. Methods: As a part of the AIM-TBI study at Medisch Spectrum Twente and Universitair Medisch Centrum Groningen, EEG alpha features in mTBI patients were compared in acute ($<$24 hours after the injury)(N=18) and subacute (24h-1 month after the injury)(N=19) phase and compared to a healthy control group (N=20). Correlations between EEG alpha features in mTBI patients and non-electroencephaloraphical features like reaction time and Head Injury Symptom Checklist scores were investigated. Two EEG measurements were performed: a resting state EEG (rsEEG), alternating between 3 minutes eyes closed and eyes open and an EEG during a computerized reaction time choice (CRT) task. Alpha peak frequency, alpha reactivity, averaged alpha power and reaction time were extracted. The mTBI subject filled in a Head Injury Symptom Checklist (HISC) questionnaire 2 weeks, 4-6 weeks and 6 months after the injury and a HISC score was extracted, used as a measure of post-conscussive complaints. Results: Alpha power reactivity in the acute phase was decreased compared to the subacute phase during the rsEEG (N=10). Absolute total alpha power was increased for both phases (N=10) compared the healthy controls (N=20)during the CRT task. A decrease in relative alpha for the acute phase and increase in subacute phase compared to the controls was seen during the CRT task. An increase in absolute alpha power at the end of the CRT task compared to the beginning was found for subacute group, which was not present in the acute group. None of differences were statistically significant ($p>0.05$). Alpha reactivity correlated negatively with reaction time for the acute group (N=9) and for the acute and subacute group combined (N=19). Alpha peak frequency and HISC score correlated negatively (N=63). A weak negative trend was found between the alpha reactivity and HISC score (N=63). Conclusion: Some differences were found in alpha EEG features between acute and subacute phase in mTBI patients compared to healthy controls, but none were statistically significant. Reaction time and alpha reactivity and alpha peak frequency and HISC score correlated negatively. \\
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:30 exact sciences in general, 44 medicine
Programme:Biomedical Technology BSc (56226)
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