University of Twente Student Theses
Optimization of a human CHD8 suppressed blood-brain barrier model
Baumeister, A.S.M. (2022) Optimization of a human CHD8 suppressed blood-brain barrier model.
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| Abstract: | An increasing number of children is being diagnosed with autism spectrum disorder (ASD), characterized by deficits in social communication and restrictive repetitive actions. 50 – 80% of ASD diagnosed children also experience sleep problems, which has a big impact on quality of life for both child and parent. A correlation is found in ASD diagnosed children between mutation of chromodomain-helicase-DNA-binding protein 8 (CHD8) and having sleep problems. Since it is known that the blood-brain barrier (BBB) is involved in sleep regulation, the goal of this research was to optimize a CHD8 suppressed BBB model to study barrier integrity. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 42 biology, 50 technical science in general |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/90991 |
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