University of Twente Student Theses


Optimization of a human CHD8 suppressed blood-brain barrier model

Baumeister, A.S.M. (2022) Optimization of a human CHD8 suppressed blood-brain barrier model.

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Abstract:An increasing number of children is being diagnosed with autism spectrum disorder (ASD), characterized by deficits in social communication and restrictive repetitive actions. 50 – 80% of ASD diagnosed children also experience sleep problems, which has a big impact on quality of life for both child and parent. A correlation is found in ASD diagnosed children between mutation of chromodomain-helicase-DNA-binding protein 8 (CHD8) and having sleep problems. Since it is known that the blood-brain barrier (BBB) is involved in sleep regulation, the goal of this research was to optimize a CHD8 suppressed BBB model to study barrier integrity.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:42 biology, 50 technical science in general
Programme:Biomedical Engineering MSc (66226)
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