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Ablation in navigation bronchoscopy for non small lung cancer : "Which ablation technique: microwave ablation, radiofrequency ablation, cryoablation or irreversible electroporation, is most suitable in combination with navigation bronchoscopy for patients with stage I and IIA non small cell lung cancer whom are not eligible for surgery and stereotactical radiotherapy?"

Buijs, M.J.H. and Peters, S.H.J.M. and Vroling, C. and Haalstra, S. (2022) Ablation in navigation bronchoscopy for non small lung cancer : "Which ablation technique: microwave ablation, radiofrequency ablation, cryoablation or irreversible electroporation, is most suitable in combination with navigation bronchoscopy for patients with stage I and IIA non small cell lung cancer whom are not eligible for surgery and stereotactical radiotherapy?".

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Abstract:Introduction: Currently, patients with non small cell lung cancer and comorbidities cannot be treated with surgery or stereotactic radiotherapy. A less invasive treatment has to come in practice, for which ablation; microwave ablation (MWA), radiofrequency ablation (RFA), cryoablation or irreversible electroporation (IRE), in combination with navigation bronchoscopy, is a viable option. This results in the question: which of the ablation techniques is most suitable for patients with non small cell lung cancer (NSCLC) stage I and IIA? Method: The research question is answered using subquestions, some of which are answered through literature, one question was answered experimentally. IRE and cryoablation were executed on bovine lung using different settings. Post ablation, scans were made with cone-beam computed tomography (CBCT) to analyze the volume of the ablation zone. Results: IRE and cryoablation are most promising due to their tissue-sparing way of ablation and potential immunoregulation abilities. RFA and MWA are applicable but are not preferable near the pleura or large vessels. This is due to their destroying capabilities and heat sink effect. The CBCT scans demonstrated no clear results of ablation zones, observations made during the experiment are mentioned. Conclusion: Which ablation technique is most suitable is patient and situation specific.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine BSc (50033)
Link to this item:https://purl.utwente.nl/essays/91377
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