University of Twente Student Theses


Development of a Nikkiso Dialysis Device Protocol for In-house Dialyzers

Jong, E. de (2022) Development of a Nikkiso Dialysis Device Protocol for In-house Dialyzers.

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Abstract:In hemodialysis blood is pumped through a dialyzer (containing about 8000 fibers) to remove toxins and excess of water when the patient’s kidneys have a glomerular filtration rate smaller than 15 mL/min/1.73 m2. There are a lot of different dialyzers on the market to improve the removal and adapt to patient’s needs. Within the Advanced Organ bioengineering and Therapeutics department of the University of Twente, small, in-house dialyzers (containing either 10 or 25 fibers) are prepared to improve toxin removal. To test these dialyzers in a clinical way, the dialyzers will be tested using a Nikkiso dialysis device (DBB-05). In this study experiments are performed using the dialysis device and a circuit containing a large, commercial dialyzer (F X80classix, Fresenius Medical Care), Hoffmann clamps and circulated dialysate (Qb = 15 mL min−1, Qd = 30 mL min−1). Subsequently, the small, in-house dialyzer (containing 50 F X1000 fibers of Fresenius Medical Care) is placed next to the large dialyzer in the circuit and 4 hours dialysis experiments with creatinine are performed (Qb = 15 mL min−1, Qd = 30 mL min−1). The results show that the coupling of small, in-house dialyzers containing 50 fibers works and that experiments can be performed. The creatinine removal of the small, in-house dialyzer is larger than the removal of the large, commercial dialyzer. It is expected that this is due to the small flow rate per fiber passing through the large, commercial dialyzer.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Biomedical Technology BSc (56226)
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