University of Twente Student Theses


Development of hollow fiber membranes prepared with the green solvent Agnique® AMD 3L for haemodialysis

Pater, S. (2022) Development of hollow fiber membranes prepared with the green solvent Agnique® AMD 3L for haemodialysis.

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Abstract:A patient with end stage renal disease (ESRD) has malfunctioning kidneys that do not filter out ure- mic toxins as one’s kidneys normally do. Haemodialysis (HD) is an important alternative therapy for patients with renal failure that are unable to receive a donor kidney. HD cleanses the blood of ESRD pa- tients by filtering it using membranes that are compatible with blood and have a high fouling resistance. A lot of the membranes that are currently in use are produced by blending a hydrophobic polymer, such as polyethersulfone (PES), with a hydrophilic polymer, like polyvinylpyrrolidone (PVP). Frequently the phase inversion immersion precipitation technique is used to prepare these membranes, for which a sol- vent needs to be added to the polymer solution. A commonly used solvent for this technique is N-methyl pyrrolidone (NMP), because of its great stability. However, NMP is a toxic solvent that is hazardous to use and is harmful for the environment as well as the patients. Thus, to make the membranes less toxic for patients and less harmful for nature, green solvents have been introduced. Agnique® AMD 3 L (N,N- dimethyl lactamide; AMD) is one of these solvents, and is used in this study to investigate its potential for preparing suitable fibers for HD. Here, hollow fiber membranes have been developed using AMD that have a similar structure to the ones already being used commercially. The developed fiber has a high porosity and good stability, which shows potential for a fiber suitable for HD.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:50 technical science in general, 51 materials science
Programme:Biomedical Technology BSc (56226)
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