University of Twente Student Theses
Development of a Joint-on-Chip Platform to Study Chondro-Synovial Crosstalk in Arthritis The Development of a Common Culture Medium for Proof-of-Concept Experiments
Spoelstra, L.R. (2022) Development of a Joint-on-Chip Platform to Study Chondro-Synovial Crosstalk in Arthritis The Development of a Common Culture Medium for Proof-of-Concept Experiments.
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| Abstract: | Arthritis is a family of diseases affecting millions of people globally, leading to reduced quality of life and, in severe cases, disability. The two most common forms of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA), accounting for 1,8 million patients in the Netherlands only. To date, no drugs are available for OA that treat the disease, and only a few for RA, which have severe systemic side-effects. Drug development for arthritis is hampered by the lack of physiologically relevant preclinical models; the gold standard models are either too simplifed to replicate the complex pathogenesis of arthritis or involve the use of animal models that have different joint physiology. Therefore, there is a clear need for more predictive preclinical models. In recent years, Organs-on-Chips (OoCs) for cartilage (CoC) and the synovial membrane (SoC), two tissues involved in the pathogenesis of arthritis, developed by the DBE and AMBER groups, have been used to study joint physiology and pathology. However, these OoCs do not mimic the biochemical chondro-synovial communication in the joint, which is present in both OA and RA. Therefore, a Joint-on-Chip (JoC) has been proposed that combines the CoC and SoC platforms to mimic this communication. The development of a JoC poses two major (bio)engineering challenges: the appropriate downscaling of the in vivo joint (scaling), and the development of a common culture medium (CCM) to be recirculated in the JoC. Therefore, this thesis aimed to address these challenges for future implementation of the JoC. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 42 biology, 44 medicine |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/92919 |
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