University of Twente Student Theses


Computational Fluid Dynamics for Personalized Airway Stents

Beelen, S.M.J. van (2022) Computational Fluid Dynamics for Personalized Airway Stents.

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Abstract:Of all lung cancer patients, 30% develops an obstruction of the airway. A conventional airway stent can be placed but is prone to complications. Personalized stents may overcome these complications since these are based on the patients’ CT-data and therefore more congruent to the airway. However, quantitative evidence and underlying processes of conventional stent complications remain unknown, hence no improvement in stent design can be done. Therefore, computational fluid dynamics (CFD) in stents and airways can be used. This thesis aims to obtain quantitative evidence for the use of personalized airway stents, by simulating airways and stents with CFD. In short, CFD quantitatively evaluated clinical effects of stent placement for one case. Conventional airway stents decrease the work of breathing and airway wall damage, compared to the obstructed situation. However, poor congruence to the airway wall, sub-optimal use and still increased chance of complications compared to the pre-obstructed situation presented. Therefore, CFD prove that conventional airway stents have room for improvement and the clinical outcome can be improved. Personalized airway stents can improve congruence and subsequently virtually simulate these designs within the airway, to predict the clinical outcome.
Item Type:Essay (Master)
Antoni van Leeuwenhoek
Faculty:TNW: Science and Technology
Subject:33 physics, 44 medicine
Programme:Technical Medicine MSc (60033)
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