University of Twente Student Theses


Cutting-edge Neurosurgical Technology: Working Towards New Surgical Strategies in Pediatric Neuro-oncology

Klein Gunnewiek, Kevin (2023) Cutting-edge Neurosurgical Technology: Working Towards New Surgical Strategies in Pediatric Neuro-oncology.

Full text not available from this repository.

Full Text Status:Access to this publication is restricted
Embargo date:7 September 2025
Abstract:Surgical resection of pediatric brain tumors remains challenging due to limited visualization of tumor boundaries. Novel technical modalities have been introduced to enhance this process, aiming to improve efficiency, effectiveness, and safety of surgery. This study focuses on evaluation of technical modality usage and assessing navigated intraoperative ultrasound (iUS) for tumor visualization and residual assessment. In the first part, a survey study evaluated intraoperative technical modalities using Likert scores, yielding best practices and challenges. Eventually, guidelines are proposed for optimal modality integration. In the second part, the diagnostic value of navigated iUS was quantified as compared to intraoperative MRI (iMRI) for diagnostic value. Quantitative metrics like Dice similarity coefficient, Hausdorff distance, and volumetric differences were used. Navigated iUS demonstrated high sensitivity (100%) and specificity (80%) in detecting residual tumors. Moderate DSC (0.61), median HD 95th percentile (5.84 mm), and volume difference (0.82 cm3) were observed post-resection. Pre-resection visualization exhibited a good DSC (0.71), median HD 95th percentile (4.61 mm), high volumetric correlation with iMRI (R=0.996), and median volume difference (1.28 cm3). The study underscores different technical modality implementation between prone and supine procedures and validates navigated iUS as a valuable diagnostic tool for tumor detection. Navigated iUS demonstrated to be a good alternative if iMRI is not available.
Item Type:Essay (Master)
Princess Máxima Center, Utrecht, The Netherlands
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:
Export this item as:BibTeX
HTML Citation
Reference Manager


Repository Staff Only: item control page