University of Twente Student Theses
The Effectiveness of Lysergic Acid Diethylamide to Increase Well-being and Related Positive Mental Health Outcomes in Healthy Individuals : A Systematic Review of Placebo-Controlled Trials
Marquardt, Jana (2023) The Effectiveness of Lysergic Acid Diethylamide to Increase Well-being and Related Positive Mental Health Outcomes in Healthy Individuals : A Systematic Review of Placebo-Controlled Trials.
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| Abstract: | There is currently a lack of research into the positive psychological properties of psychedelic substances. Although psychedelics already demonstrated the potential to elevate well-being in individuals there are currently no systematic reviews on the topic. Therefore, this systematic literature review investigates the effectiveness of lysergic acid diethylamide (LSD) in increasing well-being and related positive mental health outcomes in individuals. Several search engines were systematically searched for peer-reviewed and placebo- controlled clinical trials, including information on the effect of LSD on well-being and on components of the PERMA model of well-being. Afterward, 8 studies were analysed, and their results were synthesised. The results showed inconsistent positive effects of LSD on well-being. However, with an increase in dosage, the consistency of positive effects grew with the most consistent effects at 200μg. Moreover, the effect of LSD on the components positive emotions, meaning, and relationships from the PERMA model was positive while evidence for the components accomplishment and engagement was lacking. Based on the results of the current study, a positive effect of LSD on well-being especially at high dosages seems likely. Regarding the components from the PERMA-model, a positive effect on concepts related to positive emotions, relationships, and meaning is probable. It was not possible to determine why accomplishment and engagement were not included in the literature, but a possible explanation could be the ego perception during mystical-type experiences. Nevertheless, due to a significant number of limitations of the analysed studies, such as the risk of carry-over effects and the lack of long-term measures, these conclusions need to be interpreted cautiously. |
| Item Type: | Essay (Master) |
| Faculty: | BMS: Behavioural, Management and Social Sciences |
| Subject: | 77 psychology |
| Programme: | Psychology MSc (66604) |
| Link to this item: | https://purl.utwente.nl/essays/97287 |
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