University of Twente Student Theses
Transcutaneous electrical stimulation modulates persistent inward currents in spinal cord injury subjects: a model-based study
Zantingh, O.I. (2023) Transcutaneous electrical stimulation modulates persistent inward currents in spinal cord injury subjects: a model-based study.
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| Abstract: | Spasticity is a highly prevalent motor-impaired condition among spinal cord injury patients and stroke survivors. Transcutaneous spinal direct current stimulation (tsDCS) aims to improve the modulation of spinal excitability in individuals with spasticity. Multiple mechanisms may play a role in spinal excitability regulation in spastic patients, with Ca2+- related PICs being a significant factor. By utilising computational motoneuron models, this thesis will explore the influence of PICs in explaining the observed changes in motor neuron activity among SCI patients following cathodal tsDCS. The goal is to establish a quantifiable metric that characterises the impact of specific stimulation therapies, providing a valuable tool for clinical applications. Specifically, this project focuses on identifying the firing characteristics associated with tsDCS in experimental data and analysing the sensitivity of the model parameters in explaining these features. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Subject: | 50 technical science in general |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/97306 |
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