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Creating a hypoxic environment in a chip : Developing a hydrid hydrogel to mimic the hypoxic breast tumor microenvironment with an organ-on-chip platform.

Leunissen, Iris (2023) Creating a hypoxic environment in a chip : Developing a hydrid hydrogel to mimic the hypoxic breast tumor microenvironment with an organ-on-chip platform.

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Abstract:Cancer is the second-leading cause of death worldwide. The survival rate increased in recent years, but some cancers are still not treatable. The most common cancer in 2020 was breast cancer which was also in the top 5 of deadliest cancers. When the tumor grows a hypoxic core forms and long-term exposure to hypoxia can increase the aggressiveness and resistance to therapy of the cancer. To better understand the cancer progression and for the development of more effective treatments, it is essential to be able to mimic the tumor microenvironment with in vitro studies. The goal of this assignment was to develop a hybrid hydrogel to be able to incorporate oxygen scavengers, sodium sulphite and Oxyrase, to mimic the hypoxic microenvironment found in nature breast tumor tissues in an organ-on-chip platform. The project proceeds in three main steps. The first step was about the chip design, followed by the production and validation of the chip. The second step focussed on the microgel formation. The last step concerned the oxygen scavengers. At last, all the different aspects were combined and a hypoxic environment was created using a hybrid hydrogel in a breast tumor-on-chip platform.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:35 chemistry, 42 biology, 50 technical science in general
Programme:Biomedical Engineering MSc (66226)
Link to this item:https://purl.utwente.nl/essays/97564
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