University of Twente Student Theses


Combining needle arthroscopy with near-infrared spectroscopy to assess articular cartilage quality

Bos, Mathilde (2023) Combining needle arthroscopy with near-infrared spectroscopy to assess articular cartilage quality.

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Abstract:This project addresses the challenge of early detection and evaluation of osteoarthritis (OA), an articular cartilage disease with limited regenerative capacity. Current diagnostic techniques like MRI and arthroscopy have limitations, necessitating the exploration of novel approaches. The study focuses on extending needle arthroscopy with near-infrared (NIR) spectroscopy for improved and quantitative cartilage assessment. Through literature review and expert interviews at Amsterdam UMC, hardware design requirements were formulated, focusing on the Arthrex® Nanoscope needle arthroscope. A pilot study using single fiber reflectance spectroscopy (SFRS) was conducted on rabbit cartilage, aiming to distinguish between damaged and undamaged cartilage. Results indicate that SFRS, with its compact design and micron-sized fibers, can successfully identify differences in reflectance between healthy and damaged cartilage. However, limitations include the visible light wavelength range restriction in the pilot study, limiting examination of cartilage composition. The project also encountered challenges related to the limited data obtained and the optimal orientation of the fiber tip during SFRS. Achieving an optimal physical angle with the fiber, remains a challenge. To address these limitations, the study emphasizes the need for further research, suggesting a repetition of the investigation to gather more data and optimize the fiber's contact with cartilage for accurate evaluation.
Item Type:Essay (Bachelor)
Amsterdam UMC
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Biomedical Technology BSc (56226)
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