University of Twente Student Theses
Localization and Planar Control of Nanoparticle-Coated Sperm Cells In Vitro
Mulder, Iris (2024) Localization and Planar Control of Nanoparticle-Coated Sperm Cells In Vitro.
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| Abstract: | IRONSperm has remarkable potential to be used in the medical field for targeted drug delivery and assisted fertilization. Previous research has focused on characterization and one-dimensional movement of these microrobots, utilizing a stationary RPM. The aim of this study is to assess the feasibility of planar locomotion control, both in an unbounded environment and within a trifurcation phantom. Trials in an unbounded environment have demonstrated the importance of correct alignment of the RPM with respect to the cluster’s confinement. Additionally, manual control of the RPM was found to have a positive effect on following the predefined trajectories more closely, particularly during joint movements. A proof of principle was established of successfully navigating a 3 mg/mL IRONSperm cluster to the left, straight and right branch in a trifurcation phantom with success rates of 64.2%, 58.3%, and 34.6%, respectively. Locomotion control has also proven possible towards the right and left fallopian tube in a real-size phantom of the female reproductive tract. The clusters have been visualized utilizing X-Ray. More research should be carried out to improve the accuracy of locomotion control and to investigate IRONSperm locomotion when facing differently structured surfaces and environments. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/98187 |
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