University of Twente Student Theses
Simulating the Placenta in a Hemodynamic Model of the Pregnant Woman : Technisch Geneeskundige Opdracht - Radboudumc
Boer, Jedidja R. and Burg, Birgit K. van der and Naber, Veronie M.A and Ven, Sanna H.A. van de (2023) Simulating the Placenta in a Hemodynamic Model of the Pregnant Woman : Technisch Geneeskundige Opdracht - Radboudumc.
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| Abstract: | Introduction. The placenta is the organ that exchanges nutrients between mother and child. This means that when the placenta develops or functions poorly, it results in malnourishment of the fetus and complications during pregnancy. As the placenta plays a crucial role in these complications, it is important to get a better understanding of the (mal-)functioning of the placenta. Methods. By using an existing hemodynamic model from Radboudumc and defining values of resistances, elastances and initial and unstressed volumes, the pressures, and flows of the uterine arteries, spiral arteries, intervillous space and uterine veins could be examined. The values were defined for the first and second trimester of a healthy pregnancy and for the second trimester of gestational hypertension (GH), early-onset preeclampsia (PE), placenta accreta syndrome (PAS) and fetal growth restriction (FGR). Results. The simulation of the uncomplicated first and second trimester were according expectation, based on knowledge gained by literature. Adjustments made for PE, FGR and PAS resulted in a representative hemodynamic pathological profile. However, adjustments made to simulate GH did not result in hypertension. Discussion. The volume distribution within the model does not resemble reality, due to the closed-loop system. Furthermore, the model is a simplified version of reality, solely displaying pressures and flows based on compliances lumped via resistances. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Programme: | Technical Medicine BSc (50033) |
| Link to this item: | https://purl.utwente.nl/essays/98252 |
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