University of Twente Student Theses
Upscaling Production of Monodisperse Microcapsules for Injectables by In-Air Microfluidics
Ding, Daniël (2024) Upscaling Production of Monodisperse Microcapsules for Injectables by In-Air Microfluidics.
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| Full Text Status: | Access to this publication is restricted |
| Embargo date: | 4 March 2029 |
| Abstract: | The production of encapsulated microparticles is becoming increasingly important due to its wide range of applications. Microcapsules, consistent of a core and surrounded by a shell. The shell can protect the core, which could contain active ingredients, drastically increasing preservation life, but importantly control the release of pharmaceutical drugs. This lowers dosage peaks and prevent adverse side-effects. This study aimed to produce injectable (<100 µm), monodisperse (CV <10%) capsules using In-Air MicroFluidics (IAMF), which is ten to hundredfold faster than conventional chip-based techniques, since it is based on the jetting of fluids. Beside the geometric conditions, the inertial and viscous interaction between the core- and shell flow had to be calibrated carefully to achieve monodisperse break-up of single-core capsules. It was hypothesized that the interaction between core fluid and the nozzle walls caused instability of the jet and hence capsule formation, so called core collision. This study analysed this problem qualitatively, with an extension to a quantitative validation study regarding the formation and break-up of the compound jet. When stability is achieved, a proof of concept had been developed with sunflower oil core and alginate shell capsules below 100 µm. First upscaling steps were performed to increase throughput rate up to a fourfold. This was extended to the formation of injectable PLGA particles. PLGA is typically used as a biodegradable drugcarrier for pharmaceutical applications. With this, injectable solid PLGA microparticle were produced, but also, PLGA micrcapsules <150 µm were produced. In conclusion, advancements were made regarding the IAMF technique by understanding the parameters of interest in the formation of compound microjets below 100 µm, whereby initial steps were set in terms of production upscaling as well as developing an actual proof of concept, relevant to bio-pharmaceutical applications. |
| Item Type: | Essay (Master) |
| Clients: | Iamfluidics, Enschede, Netherlands |
| Faculty: | ET: Engineering Technology |
| Subject: | 33 physics, 52 mechanical engineering |
| Programme: | Mechanical Engineering MSc (60439) |
| Link to this item: | https://purl.utwente.nl/essays/98323 |
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