University of Twente Student Theses
Development of a bladder phantom to use with OCT and miniature camera experiments performed by the robot-controlled catheter of the Next-Gen In-Vivo project
Lingen, A.C. ter (2022) Development of a bladder phantom to use with OCT and miniature camera experiments performed by the robot-controlled catheter of the Next-Gen In-Vivo project.
|
PDF
10MB |
| Abstract: | The global bladder cancer mortality rate of 212.536 (2020) can be reduced when diagnostic techniques are improved. For the Next-Gen In-Vivo project a robot-controlled catheter is developed that uses Optical Coherence Tomography (OCT) and a miniature camera to make a 3D reconstruction of a bladder to easily localize and categorize a bladder tumour. To test this new diagnostic technique a phantom that represents the characteristics of a human bladder is necessary. In this report the development of such a bladder phantom is described. The inclusion of the different bladder layers, urothelium, lamina propria and muscularis propria, and different bladder tumour types is investigated. Each bladder layer and tumour type has its own optical properties. These optical properties were achieved by mixing different concentrations of scattering agents into a base material for each layer and tumour. Three different base materials, namely Dragon Skin, Ecoflex and plastisol, and two different scattering agents, namely titanium dioxide and silica, were used. Different combinations of these base materials and scattering agents were tested for the creation of a bladder phantom. A new fabrication process has been developed by combining existing methods for the creation of (bladder) phantoms and including new techniques. In short, the sandwich moulding technique is used whereby different numbers of aluminium foil layers are wrapped around the inner part of the mould to fabricate a textured semi-spherical wall phantom, consisting of layers that have thicknesses that are normally too small to be achieved by the sandwich moulding technique. In separate test pieces the different bladder tumour types were included. The phantoms and tumour test pieces were imaged by OCT, ultrasound and a miniature camera. The OCT images did not show a three layered structure, but many of the ultrasound images did. Therefore, the intensities and thicknesses of the layers could be evaluated for the different phantoms and the tumour characteristics for the different test pieces by using the ultrasound scans. Moreover, the texture of the inner surfaces of the phantoms was visualised by the miniature camera and compared to the lining of a human bladder. Some further improvements have to be made to make the phantoms even more realistic, but a proper new prototype of a phantom to use for tests with the robot-controlled catheter has been made. |
| Item Type: | Essay (Bachelor) |
| Faculty: | EEMCS: Electrical Engineering, Mathematics and Computer Science |
| Subject: | 50 technical science in general |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/98351 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
Show download statistics for this publication
Show download statistics for this publicationRepository Staff Only: item control page