University of Twente Student Theses
Real-time analysis of Dynamic Contrast Enhanced Ultrasound for catheter position optimisation in Transarterial Radioembolization : a proof-of-concept study in an ex-vivo perfused porcine model
Visser, Adrie (2024) Real-time analysis of Dynamic Contrast Enhanced Ultrasound for catheter position optimisation in Transarterial Radioembolization : a proof-of-concept study in an ex-vivo perfused porcine model.
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| Abstract: | Transarterial Radioembolisation is a treatment option for unresectable liver tumours. In this treatment, a microcatheter is guided towards the hepatic arteries supplying the tumour, to selectively inject radioactive microspheres which embolise the capillaries and locally irradiate the tissue. However, the absence of real-time visualisation of the microsphere deposition during the treatment can lead to sub-optimal targeting of the tumour and unpredicted off-side toxicity. As the effectiveness of the treatment is related to the tumour absorbed dose, the microsphere deposition at the tumour location should be optimised. We present here for the first time an augmented Transarterial Radioembolisation protocol using a combination of microbubbles and real-time quantification of Dynamic Contrast Enhanced Ultrasound data to provide visual feedback during the treatment. For this purpose, an in-house algorithm with the capacity to instantly generate and quantify Time Intensity Curves was developed. In a carefully controlled laboratory setting, using an ex-vivo perfused porcine liver, we demonstrate that the live feedback of our novel approach enabled efficient optimisation of the catheter position such that a predefined area is targeted. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 33 physics, 42 biology, 44 medicine, 46 veterinary medicine, 50 technical science in general |
| Programme: | Biomedical Engineering MSc (66226) |
| Awards: | Poster Prize of the Cancer Therapy session - The 29th European symposium on Ultrasound Contrast Imaging |
| Link to this item: | https://purl.utwente.nl/essays/98394 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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