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Source reconstruction of ANT-DBS induced evoked potentials and epileptiform discharges in patients with refractory epilepsy

Loosveld, L.H.G. (2024) Source reconstruction of ANT-DBS induced evoked potentials and epileptiform discharges in patients with refractory epilepsy.

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Abstract:Epilepsy is a neurological disorder characterized by recurrent seizures which is primarily treated with medication. However, 30% to 40% of the patients are refractory to drug treatment and neuromodulation interventions, such as deep brain stimulation (DBS), have emerged as potential alternatives for these patients. To advance our understanding, in this thesis, we investigated DBS-triggered evoked potentials recorded at the scalp and the personalized overlap in cortical activation maps for the DBS-triggered and epileptic activity. The temporal progression of dipoles based on hemisphere-wise stimulation exhibited similarities. However, differences in lateralization occurred. For the even peaks, the sources were localized in the thalamus and cingulate gyrus, which is consistent with the hypothesis of the circuit of Papez being involved after DBS. For the odd peaks, the source analysis resulted in more lateral dipoles, raising considerations about electrode mapping accuracy or spatial resolution limitations in the source reconstruction pipeline. In the case of the more generalized epileptic activity, we see a partial overlap between the DBS map and the epileptic map. Additional research is crucial to establish robust conclusions regarding DBS and epilepsy map overlaps. However, the insights gained from this research could play a pivotal role in influencing epilepsy treatment strategies.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Biomedical Engineering MSc (66226)
Link to this item:https://purl.utwente.nl/essays/98477
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