University of Twente Student Theses


Characterisation of VNS-induced evoked potentials in epilepsy patients.

Krabbe, T. (2023) Characterisation of VNS-induced evoked potentials in epilepsy patients.

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Abstract:Background: For drug resistant epilepsy, alternative treatments are necessary. Vagus Nerve Stimulation (VNS) is one such safe, palliative treatment, however, a lack of understanding in both its inner workings and regarding the optimal stimulation parameters lead the treatment to being prolonged and often ineffective. EEG can help in this analysis. Objective: The goal is to analyse evoked potentials induced by VNS to build upon previous research and further characterise the short latency components common in VNS. Method: 30 minute VNS EEG-data from 5 patients was segmented into 30 ms trials, after which evoked potentials were plotted and characterised according to VNS input parameters. Topographical plots were also made, which depicted the electrical potential in the scalp directly after VNS. Results: A 10 ms peak was visible in all patients, with a new 5 ms peak appearing in 2 patients, which also seemed to affect spatial reactions in the topographical plots. Input parameters did not seem to have a significant effect on peak-amplitude across these patients. Conclusions: This study provides valuable insights into VNS-induced evoked potentials in epilepsy patients, uncovering an unexpected peak at approximately 5 ms in specific datasets. Further research is needed to explore these findings, refine analysis methods, and enhance understanding of the impact of VNS on brain dynamics. Keywords: Epilepsy, Vagus nerve stimulation, Evoked potential
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:02 science and culture in general, 42 biology, 50 technical science in general
Programme:Biomedical Technology BSc (56226)
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