University of Twente Student Theses


The effects of NR-TMS language mapping on brain activity using HD-EEG : from setup to analysis

Haren, S.L. van (2024) The effects of NR-TMS language mapping on brain activity using HD-EEG : from setup to analysis.

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Embargo date:13 March 2028
Abstract:This study aims to investigate the effect of nr-TMS on brain activity and language network mapping using HD-EEG during language tasks in healthy individuals. A custom-made combined test setup was constructed in order to conduct the study and ethical approval was acquired. Continuous 64-channel HD-EEG recordings were measured while participants performed 75 object-naming and 75 action-naming tasks. Using MRI-guidance, the same tasks were repeated during nr-TMS to map language areas. From the HD-EEG we calculated the amplitude and latency of the P300 Event-Related Potential (ERP) component. Next, additional ERP components were investigated. Finally, readouts such as the averaged topography and power spectra were assessed. We have confirmed the functioning of our custom made combined test setup and gathered reliable results. We also confirm that our pre-processing of the TMS-EEG-data is sufficient to allow for comparison to the baseline HD-EEG data and explore language networks. Although our analytical methods provide valuable insights, due to the limited sample size of our study, we are not able to draw any conclusive statements. We recommend repeating this study on a larger group of subjects, exploring other EEG-network analysis measures, Further improving the combined test setup and including patients suffering from LGG in language area.
Item Type:Essay (Master)
UMCG, Groningen, The Netherlands
UMCG, Groningen, The Netherlands
Faculty:TNW: Science and Technology
Subject:17 linguistics and theory of literature, 44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
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