University of Twente Student Theses
Designing a synthetic model of the esophagus to test efficacy and oxygen distribution of an intelligent oxygen delivery device
Prins, N.M. and Ochten, M. van and Steen, D. van der and Wiggers, R.B.M. (2017) Designing a synthetic model of the esophagus to test efficacy and oxygen distribution of an intelligent oxygen delivery device.
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| Abstract: | The aim of this study was to develop and validate a synthetic model, representa- tive of the esophagus, to investigate oxygen distribution by an intelligent oxygen delivery device after esophageal resection. 10% of the patients who undergo an esophagectomy develop anastomotic dehiscence which is frequently the result of ischemia of the gastric conduit. The effectiveness of oxygen application for prevention of ischemia surrounding the anastomosis after intestinal resection has been implied in a study conducted on pigs. Since research on animals is expensive and ethically hard to justify, it would be preferable to develop a synthetic model that could be used to test prototypes of an intelligent oxygen delivery device. Various polymer-based gels and membranes, as well as porcine esophageal tissue, were exposed to oxygen on one side to determine their oxygen permeability. On the other side, the change in oxygen concentration was measured. The measurements indicate a linear trend of oxygen permeation through the different membranes over time. Using these measurements and formulas derived from Ficks laws, the per- meability of the different membranes and tissue were calculated. From the measurements performed in this study, it can be concluded that a PDMS membrane with a thickness of 0.7 millimeter is most representative of the porcine esophageal tissue of 7 millimeters in terms of oxygen permeation. To test prototypes of an intelligent oxygen delivery device in the future, it is recommended to develop a model with a PDMS membrane with the calculated thickness. A design of such a model is presented in this report. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Subject: | 30 exact sciences in general, 33 physics, 42 biology, 44 medicine, 50 technical science in general |
| Programme: | Technical Medicine BSc (50033) |
| Link to this item: | https://purl.utwente.nl/essays/72610 |
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