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CFD modeling of a gas exchange membrane in OpenFOAM

Frijns, M.H.C. (2017) CFD modeling of a gas exchange membrane in OpenFOAM.

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Abstract:The Wyss Institute at Harvard is developing organs-on-a-chip which are able to mimic organ functions and could even become person-specific. The largest benefit for this kind of chips is the model which is based on humans instead of animals. The predictions made are realistic and drugs can be tested for toxicity. The goal of this thesis is to build a basis for the computation of gas exchange between two uids, separated by a membrane, to support the development of such a chip. In addition, the effect of membrane degradation on the gas exchange is implemented and reviewed to provide a starting point in expanding the model properties. The open-source CFD software OpenFOAM is used for mathematical simulations of the convective and diffusive fl ows of a generic gas species through a membrane. The model is verified with both spatial and temporal grid refinement studies and their convergence. Membrane degradation is implemented in the model to apply both time and concentration dependent diffusion coefficient decline. An equation was created and implemented to simulate the degradation and partial healing of a membrane due to a concentration peak. Due to the adjustable parameters in this equation, the profile of the concentration dependent diffusion coefficient can be manipulated to obtain the desired outcome. This provides proof of the applicability of OpenFOAM as a CFD software to model gas exchange and contributes a basis to apply concentration dependent membranes in a model.
Item Type:Essay (Master)
Clients:
Unknown organization, Nederland
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Subject:31 mathematics
Programme:Applied Mathematics MSc (60348)
Link to this item:http://purl.utwente.nl/essays/73780
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